{"id":21301,"date":"2023-04-17T22:15:04","date_gmt":"2023-04-17T22:15:04","guid":{"rendered":"https:\/\/www.ataxia.org\/?p=21301"},"modified":"2025-02-10T10:28:43","modified_gmt":"2025-02-10T16:28:43","slug":"2023-funded-research","status":"publish","type":"post","link":"https:\/\/www.ataxia.org\/2023-funded-research\/","title":{"rendered":"2023 Funded Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"21301\" class=\"elementor elementor-21301\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-54b596d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"54b596d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f87832a\" data-id=\"f87832a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0578a15 elementor-widget elementor-widget-spacer\" data-id=\"0578a15\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd0450a elementor-widget elementor-widget-heading\" data-id=\"dd0450a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">NAF to Award $735,000 in Ataxia research grants in 2023<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8dea98e elementor-widget elementor-widget-text-editor\" data-id=\"8dea98e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>There was a robust pool of applicants for NAF research grants in 2023. It demonstrates the energy to accelerate treatment development in this space. We were thrilled to see so many studies with high scientific merit! <span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">These grants allow Ataxia investigators to request funding for their studies to lead us closer to possible treatments.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb6bff4 elementor-widget elementor-widget-image\" data-id=\"eb6bff4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"6912\" height=\"2880\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1.png\" class=\"attachment-full size-full wp-image-21322\" alt=\"Graphic with 3 labeled circles with numbers in the middle. 112 letters of intent, 65 applications, 16 funded.\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1.png 6912w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1-300x125.png 300w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1-1024x427.png 1024w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1-768x320.png 768w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1-1536x640.png 1536w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-1-2048x853.png 2048w\" sizes=\"(max-width: 6912px) 100vw, 6912px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6073fcf elementor-widget elementor-widget-text-editor\" data-id=\"6073fcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">This year\u2019s funded projects will support research on 11+ genetic forms of Ataxia, from the most common to some of the rarest, as well as address shared disease pathways that could provide insights into ALL of the Ataxias.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-661179f elementor-widget elementor-widget-image\" data-id=\"661179f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"6912\" height=\"2880\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2.png\" class=\"attachment-full size-full wp-image-21321\" alt=\"Graphic with a pie chart to show the amount spent for research funding, which is a total of $735,000\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2.png 6912w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2-300x125.png 300w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2-1024x427.png 1024w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2-768x320.png 768w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2-1536x640.png 1536w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Research-Grant-Impact-Data-2-2048x853.png 2048w\" sizes=\"(max-width: 6912px) 100vw, 6912px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c370fc elementor-widget elementor-widget-spacer\" data-id=\"8c370fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ec9efe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ec9efe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b19eb50\" data-id=\"b19eb50\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27418b4 elementor-widget elementor-widget-spacer\" data-id=\"27418b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6df3fa elementor-widget elementor-widget-text-editor\" data-id=\"c6df3fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>For 2023, NAF is funding:<\/h3><ul><li><b>5 Research Seed Money Grants <\/b>&#8211; totaling $250,000<\/li><li><b>5 Early Career Investigator Awards<\/b> &#8211; totaling $250,000<\/li><li><b>4 Graduate Research Fellowships<\/b> &#8211; totaling $100,000<\/li><li><b>1 Pioneer SCA Translational Award<\/b> &#8211; totaling $100,000<\/li><li><b>1 Post-Doctoral Fellowship<\/b> &#8211; totaling $35,000<\/li><\/ul><p>\u00a0A full list of the research studies and their lay summaries are available below.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2464b3 elementor-widget elementor-widget-spacer\" data-id=\"a2464b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-82c4230 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"82c4230\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e68145e\" data-id=\"e68145e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4df41c5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4df41c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e7d063 elementor-widget elementor-widget-heading\" data-id=\"7e7d063\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Lay Summaries<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd32784 elementor-widget elementor-widget-spacer\" data-id=\"bd32784\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f820e34 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f820e34\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5072bb3\" data-id=\"5072bb3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d33968f elementor-widget elementor-widget-heading\" data-id=\"d33968f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research Seed Money Grants<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12a9e7e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12a9e7e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d7fe1e0\" data-id=\"d7fe1e0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-40eda50 elementor-widget elementor-widget-image\" data-id=\"40eda50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Battersby-Sized.png\" class=\"attachment-large size-large wp-image-21318\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Battersby-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Battersby-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Battersby-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a74f3e6 elementor-widget elementor-widget-text-editor\" data-id=\"a74f3e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Brendan Battersby<\/b><\/span><\/p><p>University of Helsinki, Finland\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-654b1b0\" data-id=\"654b1b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-394285f elementor-widget elementor-widget-text-editor\" data-id=\"394285f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>Investigating sources of proteotoxicity substrates with AFG3L2\/SPG7 ataxia disorders<\/strong><\/em><\/p><p><b>Ataxia Type:\u00a0<\/b>Mitochondrial ataxia with autosomal recessive and dominant origins<\/p><p>Our research investigates inherited ataxia disorders that arise from disruptions to cellular energy production. \u00a0The generation of\u00a0misfolded proteins needed for energy production is an initial event in the disease. \u00a0The goal of the Seed Funding from NAF is to identify the sources of misfolded proteins and to limit their production as a therapeutic target.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b3ab86 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b3ab86\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6efa60b\" data-id=\"6efa60b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-507f62e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"507f62e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-75a502d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"75a502d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-95c2fec\" data-id=\"95c2fec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f96ef3 elementor-widget elementor-widget-image\" data-id=\"7f96ef3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/McLoughlin-Sized-2.png\" class=\"attachment-large size-large wp-image-21308\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/McLoughlin-Sized-2.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/McLoughlin-Sized-2-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/McLoughlin-Sized-2-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acf1b28 elementor-widget elementor-widget-text-editor\" data-id=\"acf1b28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Hayley McLoughlin<\/b><\/span><\/p><p>University of Michigan Medical Center (Michigan Medicine)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80d561c elementor-widget elementor-widget-image\" data-id=\"80d561c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Janghoo-Lim-Sized.png\" class=\"attachment-large size-large wp-image-21334\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Janghoo-Lim-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Janghoo-Lim-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Janghoo-Lim-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7433ab elementor-widget elementor-widget-text-editor\" data-id=\"d7433ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Janghoo Lim<\/b><\/span><\/p>\n<p>Yale University<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-15ec3d8\" data-id=\"15ec3d8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e63e92 elementor-widget elementor-widget-text-editor\" data-id=\"2e63e92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Mapping longitudinal single-cell transcriptional dynamic vulnerabilities in SCA3 cerebella<\/em><\/strong><\/p><p><b>Ataxia Type:<\/b> SCA3<\/p><p>This proposal seeks seed funding support to map longitudinal single-cell transcriptional dynamics in vulnerable Spinocerebellar ataxia type 3 (SCA3) mouse cerebella. We will dissect how individual cell types within a heterogenous tissue contribute to pathogenesis. Furthermore, we will relate the transcriptional changes seen in SCA3 mice to single-nuclear RNA sequencing we have generated from human SCA3 cerebella. Together, we hope to uncover new roles for diverse cerebellar cell types in SCA3 and identify the molecular events underlying disease that may elucidate protective pathways and biomarkers for SCA3.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0cdea1a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0cdea1a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-991c468\" data-id=\"991c468\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d3e28a8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d3e28a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5e6e01b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e6e01b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-e50ab27\" data-id=\"e50ab27\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c2887ef elementor-widget elementor-widget-image\" data-id=\"c2887ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Thorsten-Schmidt-Sized.png\" class=\"attachment-large size-large wp-image-21316\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Thorsten-Schmidt-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Thorsten-Schmidt-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Thorsten-Schmidt-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f622f7a elementor-widget elementor-widget-text-editor\" data-id=\"f622f7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Thorsten Schmidt<\/b><\/span><\/p><p>University of T\u00fcbingen<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-eed03bb\" data-id=\"eed03bb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0c1d522 elementor-widget elementor-widget-text-editor\" data-id=\"0c1d522\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Dissecting the role of O-GlcNAcylation in polyglutamine-related spinocerebellar ataxias<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Spinocerebellar ataxias caused by Polyglutamine expansions<\/p><p>We recently identified that the ataxin-3 protein, which is mutated in Spinocerebellar ataxia Type 3, is involved a cellular protein modification process in which sugar molecules are added to proteins.<\/p><p>Influencing this process alleviated important disease processes.<\/p><p>We will now dissect the role of this modification process in other ataxias in order to identify whether our promising results can be applied to a larger group of ataxias.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b1f0b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b1f0b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b8411e2\" data-id=\"b8411e2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef018a3 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ef018a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a6cacd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a6cacd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-dc52a24\" data-id=\"dc52a24\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f125b1 elementor-widget elementor-widget-image\" data-id=\"3f125b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Watt-Sized-1.png\" class=\"attachment-large size-large wp-image-21317\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Watt-Sized-1.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Watt-Sized-1-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Watt-Sized-1-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79b84f3 elementor-widget elementor-widget-text-editor\" data-id=\"79b84f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Alanna Watt<\/b><\/span><\/p><p>The Royal Institution for the Advancement of Learning\/McGill University<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2b48acd\" data-id=\"2b48acd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b08245 elementor-widget elementor-widget-text-editor\" data-id=\"7b08245\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Biological basis for circadian disruption in SCA6<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA6<\/p><p>Most of us know that sleep is one of the best medicines. However, sleep disturbances are common in ataxia, making the promise of a good night\u2019s sleep elusive for many ataxic patients.<\/p><p>SCA6 is a form of ataxia where sleep disruption has been reported. We study a mouse model of SCA6 and report that these mice show disruption in their sleep\/wake activity patterns, as well as a downregulation in a brain receptor that is known to modulate the \u201cmolecular clock\u201d that organizes the sleep\/wake cycle in organisms. This proposal aims to uncover the biological basis for sleep deficits in SCA6.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ffb65a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ffb65a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-824fed4\" data-id=\"824fed4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b848fc2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b848fc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a43ca2b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a43ca2b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7167646\" data-id=\"7167646\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b95e70d elementor-widget elementor-widget-image\" data-id=\"b95e70d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ricardo-Mour-Pinto-Sized.png\" class=\"attachment-large size-large wp-image-21311\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ricardo-Mour-Pinto-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ricardo-Mour-Pinto-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ricardo-Mour-Pinto-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4d9d27 elementor-widget elementor-widget-text-editor\" data-id=\"f4d9d27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Ricardo Mouro Pinto<\/b><\/span><\/p><p>Massachusetts General Hospital<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-830f979\" data-id=\"830f979\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6020b62 elementor-widget elementor-widget-text-editor\" data-id=\"6020b62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>Genetic modifiers of somatic CAG expansions in spinocerebellar ataxia type 1<\/strong><\/em><\/p><p><b>Ataxia Type: <\/b>SCA1<\/p><p>Spinocerebellar ataxia 1 (SCA1) is caused by an expanded CAG repeat in the <em>ATXN1 <\/em>gene, with longer repeats being associated with earlier disease onset and worst symptoms. A hallmark of most repeat expansion disorders, including SCA1, is that the repeats are highly unstable, not only when transmitted from parent to child, but also within a patient\u2019s brain, where the repeat keeps expanding over time \u2013 <em>aka<\/em> somatic expansion. Somatic expansions significantly affect disease onset in another disorder also caused by a CAG repeat expansion \u2013 Huntington\u2019s disease (HD). The mechanism underlying this remains poorly understood in SCA1. In this study we will test if know genetic modifiers of repeat instability in HD are also involved in regulating somatic CAG expansions in SCA1. Knowing which genes also play a role in SCA1 somatic expansions will lead to identification of potential therapeutic targets.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-acb50a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"acb50a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-442a491\" data-id=\"442a491\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6efdc90 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6efdc90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-47529ab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"47529ab\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b8d317d\" data-id=\"b8d317d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f18ed0 elementor-widget elementor-widget-heading\" data-id=\"7f18ed0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Pioneer SCA Translational Research Award<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c4aff9 elementor-widget elementor-widget-spacer\" data-id=\"0c4aff9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5384707 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5384707\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-dfe7d60\" data-id=\"dfe7d60\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5da867 elementor-widget elementor-widget-image\" data-id=\"b5da867\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Maas-Sized.png\" class=\"attachment-large size-large wp-image-21307\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Maas-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Maas-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Maas-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9743e1f elementor-widget elementor-widget-text-editor\" data-id=\"9743e1f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Roderick Maas<\/b><\/span><\/p><p>Stichting Radboud Universitair Medisch Centrum (Radboudumc)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-0ebdd05\" data-id=\"0ebdd05\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f295f2d elementor-widget elementor-widget-text-editor\" data-id=\"f295f2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Looking beyond the central nervous system in SCA3: nerve and muscle ultrasound as potential imaging markers to quantify and monitor peripheral nervous system degeneration<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA3<\/p><p class=\"MsoNormal\" style=\"text-align: justify;\">Besides ataxia, patients with SCA3 frequently report bothersome muscle cramps, pain, tingling\/numbness, and loss of muscle mass due to concomitant involvement of various peripheral nervous system structures. In this study, we will use ultrasound to visualize (changes in) nerves and muscles of individuals with SCA3 across the disease spectrum, including pre-ataxic mutation carriers. Specifically, we will investigate if nerve sizes, muscle thickness, and muscle structures differ between SCA3 patients and healthy controls, but also if ultrasound abnormalities already can be detected before the onset of ataxia and if these progress over time at a 1-year follow-up visit.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-54cc9a3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"54cc9a3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6fd04dd\" data-id=\"6fd04dd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12fef05 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"12fef05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7d32002 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7d32002\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b34a83f\" data-id=\"b34a83f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8643469 elementor-widget elementor-widget-heading\" data-id=\"8643469\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Early Career Investigator Awards<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e9b535 elementor-widget elementor-widget-spacer\" data-id=\"9e9b535\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-95f7c5d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"95f7c5d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-48df6e9\" data-id=\"48df6e9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9295b89 elementor-widget elementor-widget-image\" data-id=\"9295b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Jarmon-Lees-Sized.png\" class=\"attachment-large size-large wp-image-21305\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Jarmon-Lees-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Jarmon-Lees-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Jarmon-Lees-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3aaf2f elementor-widget elementor-widget-text-editor\" data-id=\"a3aaf2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Jarmon Lees<\/b><\/span><\/p><p>St Vincent&#8217;s Institute of Medical Research<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-5a9d0ed\" data-id=\"5a9d0ed\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-806e9ef elementor-widget elementor-widget-text-editor\" data-id=\"806e9ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>MEG3 and TRIM4 as novel therapeutic targets for vascular dysfunction in Friedreich ataxia<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Friedreich&#8217;s Ataxia<\/p><p>For sufferers of the rare, degenerative disease Friedreich ataxia, heart disease is a life-threatening complication. This project uses stem cells from people with Friedreich ataxia to create a \u201cheart-in-a-dish\u201d which has allowed us to identify two genes which may contribute to heart disease. Our goal is to test if forcibly reducing the expression of these two genes can protect the heart tissue and restore healthy beating.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a95d3d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a95d3d7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1416d91\" data-id=\"1416d91\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-621b7db elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"621b7db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-05724d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"05724d7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-eadc448\" data-id=\"eadc448\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b9d4dc elementor-widget elementor-widget-image\" data-id=\"0b9d4dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Shasha-Zhang-Sized.png\" class=\"attachment-large size-large wp-image-21312\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Shasha-Zhang-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Shasha-Zhang-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Shasha-Zhang-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ef2a13 elementor-widget elementor-widget-text-editor\" data-id=\"7ef2a13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Sasha Zhang<\/b><\/span><\/p><p>The Regents of the University of Michigan<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2363bea\" data-id=\"2363bea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68ff626 elementor-widget elementor-widget-text-editor\" data-id=\"68ff626\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Metformin as potential therapeutics in FXTAS<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Fragile X-associated tremor\/ataxia syndrome (FXTAS)<\/p><p>Fragile X-associated tremor\/ataxia syndrome (FXTAS) is a neurodegenerative disorder that affects upwards of one in 500 people over the age of 50 worldwide. The disease is caused by a CGG repeat expansion that gets translated into toxic proteins through an unusual process known as RAN translation. Metformin is an FDA approved and widely prescribed drug that suppresses RAN translation in a model of ALS. With\u00a0support from NAF,\u00a0we will assess whether Metformin might also be beneficial in preclinical models of FXTAS as a precursor for clinical trials in patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cab8bc5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cab8bc5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c556aa7\" data-id=\"c556aa7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-062abc1 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"062abc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f48e71c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f48e71c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-f5f08f3\" data-id=\"f5f08f3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2995ce5 elementor-widget elementor-widget-image\" data-id=\"2995ce5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Dongwon-Lee-Sized.png\" class=\"attachment-large size-large wp-image-21303\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Dongwon-Lee-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Dongwon-Lee-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Dongwon-Lee-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1db68b8 elementor-widget elementor-widget-text-editor\" data-id=\"1db68b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Dongwon Lee<\/b><\/span><\/p><p>Baylor College of Medicine<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-859f6b6\" data-id=\"859f6b6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0c361ca elementor-widget elementor-widget-text-editor\" data-id=\"0c361ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Identifying molecular mechanisms of cerebellar hypoplasia and ataxia in CASK disorder<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Cerebellar Ataxias<\/p><p><em>CASK<\/em> disorder caused by mutations of the <em>CASK<\/em> gene has cerebellar hypoplasia and ataxia, however its pathogenesis is unknown. This proposal aims to elucidate molecular mechanisms underlying cerebellar granule cell death in <em>CASK<\/em> disorder mouse model. We expect to use this knowledge to develop new therapeutic strategies that will prevent the pathological cell death in cerebellar hypoplasia and ataxia in <em>CASK<\/em> disorder.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-41825aa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"41825aa\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-378cb46\" data-id=\"378cb46\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-298864b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"298864b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9098d1a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9098d1a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-6ab648f\" data-id=\"6ab648f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cf62806 elementor-widget elementor-widget-image\" data-id=\"cf62806\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Simone-Mader-Sized.png\" class=\"attachment-large size-large wp-image-21313\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Simone-Mader-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Simone-Mader-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Simone-Mader-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-afea181 elementor-widget elementor-widget-text-editor\" data-id=\"afea181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Simone Mader<\/b><\/span><\/p><p>LMU University Hospital Munich<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-f2f9092\" data-id=\"f2f9092\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d72f649 elementor-widget elementor-widget-text-editor\" data-id=\"d72f649\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Novel brain reactive autoantibodies directed to synaptic proteins in cerebellar ataxia<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Immune-mediated cerebellar ataxia<\/p><p class=\"Default\"><span style=\"font-size: 11.0pt;\">In the last years, several autoantibodies have been discovered, which can serve as important biomarkers and may guide therapeutic interventions, but for many patients with cerebellar ataxia, the precise pathomechanisms and the involvement of autoantibodies is unclear. With the support from NAF, we aim to characterize novel synaptic antibodies and understand their frequencies in cerebellar ataxia.<\/span><\/p><p class=\"Default\"><span style=\"font-size: 11.0pt;\">As emerging cases of antibody-mediated cognitive and behavioral impairments are identified in cerebellar ataxia and we continue to gain deeper insights on environmental factors that may trigger brain-reactive antibody response, the approach of preventing pathogenic antibodies from binding to their tissue targets may be used therapeutically in at-risk individuals.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9dd8409 elementor-widget elementor-widget-text-editor\" data-id=\"9dd8409\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Results Update (Feb 2025):\u00a0<\/b><\/p><p class=\"Default\">Immune-mediated cerebellar ataxia is associated with various autoimmune neurological disorders. While some cases have a known cause, many are still considered idiopathic. Recent studies have shown that autoantibodies, which target specific brain components, can be found in people with autoimmune neurological diseases. These autoantibodies may provide useful markers for better diagnosis and treatment. In our research, we found that 10% of patients with idiopathic cerebellar ataxia had a distinct pattern of autoantibody reactivity against cerebellar tissue. By examining cells from the patient&#8217;s cerebrospinal fluid, we were able to create monoclonal antibodies that mirrored the serum autoantibody reactivity pattern. Identifying the exact targets of these antibodies in the future could lead to improved diagnostic methods and a better understanding of the condition, potentially offering new treatment options for patients with currently unexplained ataxia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9b891b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9b891b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e67efdc\" data-id=\"e67efdc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13c0b0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"13c0b0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e54b23b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e54b23b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-ef04679\" data-id=\"ef04679\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10ba8c3 elementor-widget elementor-widget-image\" data-id=\"10ba8c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Hirofumi-Fujita-Sized.png\" class=\"attachment-large size-large wp-image-21304\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Hirofumi-Fujita-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Hirofumi-Fujita-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Hirofumi-Fujita-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96846ad elementor-widget elementor-widget-text-editor\" data-id=\"96846ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Hirofumi Fujita<\/b><\/span><\/p><p>The University of Texas Southwestern Medical Center (UT Southwestern)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-b97bec7\" data-id=\"b97bec7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d8144a elementor-widget elementor-widget-text-editor\" data-id=\"7d8144a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Defining cell type-dependent vulnerability of the dentate and Purkinje neurons in SCA3<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA3<\/p><p>While the pathology of SCA3 has primarily been investigated by focusing on the cerebellar cortex, SCA3 is also known for the prominent loss of the neurons in the cerebellar nucleus, a region responsible for mediating the information from the cerebellar cortex to the rest of the brain. In this project, by using SCA3 mutant mice, we focus on the dentate nucleus, a prominent part of the cerebellar nucleus that is known to degenerate in SCA3, to examine which specific dentate neurons and their connections from the cerebellar cortex are susceptible to this disease. With this project, we hope to start to understand the circuit pathology of the SCA3.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3bcb662 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3bcb662\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3ba18cc\" data-id=\"3ba18cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9609c52 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9609c52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0907e8b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0907e8b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f7807b4\" data-id=\"f7807b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-32763b9 elementor-widget elementor-widget-heading\" data-id=\"32763b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Post-Doctoral Fellowship<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1539ce elementor-widget elementor-widget-spacer\" data-id=\"b1539ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3bad14a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3bad14a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-08e7aa1\" data-id=\"08e7aa1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89b0db7 elementor-widget elementor-widget-image\" data-id=\"89b0db7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Stephanie-Oliveira-Sized.png\" class=\"attachment-large size-large wp-image-21315\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Stephanie-Oliveira-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Stephanie-Oliveira-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Stephanie-Oliveira-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f184ace elementor-widget elementor-widget-text-editor\" data-id=\"f184ace\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. St\u00e9phanie Oliveira<\/b><\/span><\/p><p>University of Minho<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-9ed093c\" data-id=\"9ed093c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8002f7d elementor-widget elementor-widget-text-editor\" data-id=\"8002f7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>The multimodal antidepressant vortioxetine as a therapeutic strategy to mitigate SCA3<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA3<\/p><p>My team previously showed that prolonged treatment with an antidepressant called citalopram, which increases serotonin levels in the brain, improved motor symptoms and reduced the amount of toxic ataxin-3 protein of SCA3 animal models. This work showed that targeting the serotonin systems could be a successful treatment option for SCA3. Given these promising results testing citalopram in SCA3, I will now investigate the effect of further increasing serotonin action in the brain by using a different antidepressant, called vortioxetine. Vortioxetine simultaneously targets a number of pathways within the brain, which work together to further increase the amount and activity of serotonin. We think that by using vortioxetine, an even greater reduction in motor symptoms in SCA3 animal models can be achieved.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5d1c049 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5d1c049\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d5d8521\" data-id=\"d5d8521\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-99bede2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"99bede2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4009d01 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4009d01\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5d101da\" data-id=\"5d101da\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-96b0ab1 elementor-widget elementor-widget-heading\" data-id=\"96b0ab1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">NAF Graduate Research Fellowship<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ba4008 elementor-widget elementor-widget-spacer\" data-id=\"8ba4008\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e61d867 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e61d867\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-5c19733\" data-id=\"5c19733\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0ebdf16 elementor-widget elementor-widget-image\" data-id=\"0ebdf16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ran-Ming-Sized.png\" class=\"attachment-large size-large wp-image-21310\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ran-Ming-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ran-Ming-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Ran-Ming-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a1d94d elementor-widget elementor-widget-text-editor\" data-id=\"3a1d94d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Ran Ming<\/b><\/span><\/p><p>Duke University<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2b2a523\" data-id=\"2b2a523\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e77909e elementor-widget elementor-widget-text-editor\" data-id=\"e77909e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Structural-Function Elucidation of Spinocerebellar Ataxia Type 48 (SCA48)<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA48<\/p><p>Spinocerebellar Ataxia type 48 (SCA48) is a recently discovered form of SCA that is caused by mutations to the protein C-terminus of Hsc70 Interacting Protein (CHIP). The focus of this fellowship is to understand how these mutations cause defects in CHIP function that result in SCA48. The studies proposed in this fellowship will increase our understanding of SCA48 and may lead to the identification of novel therapeutic targets.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a05080 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a05080\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07c2c21\" data-id=\"07c2c21\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cffffb2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"cffffb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b6bf4c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b6bf4c9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-38e2f97\" data-id=\"38e2f97\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23e2017 elementor-widget elementor-widget-image\" data-id=\"23e2017\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Zexin-Li-Sized-1.png\" class=\"attachment-large size-large wp-image-21333\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Zexin-Li-Sized-1.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Zexin-Li-Sized-1-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Zexin-Li-Sized-1-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed284a3 elementor-widget elementor-widget-text-editor\" data-id=\"ed284a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Jason (Zexin) Li<\/b><\/span><\/p><p>The Regents of the University of Michigan<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-96431e1\" data-id=\"96431e1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-79ac35a elementor-widget elementor-widget-text-editor\" data-id=\"79ac35a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Identification and characterization of a novel ataxia-causing SEL1L variant in humans<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>Novel hereditary human ataxia<\/p><p>SEL1L-HRD1 mediated Endoplasmic Reticulum (ER) Associated Degradation (ERAD) is a principal ER protein quality control system. We identified a SEL1L mutation that disrupted ERAD function and caused severe early onset cerebellar ataxia in human patients. Determining the significance of this SEL1L mutation can shed light on the pathogenesis of cerebellar ataxia and provide novel therapeutic strategies for these patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b78fbc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b78fbc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd05855\" data-id=\"fd05855\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7474378 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7474378\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6caa841 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6caa841\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-bae2a52\" data-id=\"bae2a52\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73cc7d4 elementor-widget elementor-widget-image\" data-id=\"73cc7d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Changwoo-Lee-Sized-1.png\" class=\"attachment-large size-large wp-image-21319\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Changwoo-Lee-Sized-1.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Changwoo-Lee-Sized-1-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Changwoo-Lee-Sized-1-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3747a9f elementor-widget elementor-widget-text-editor\" data-id=\"3747a9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Changwoo Lee<\/b><\/span><\/p><p>Yale University<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-6915de5\" data-id=\"6915de5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf71fbc elementor-widget elementor-widget-text-editor\" data-id=\"bf71fbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Identifying the Role of Oligodendroglia in Spinocerebellar Ataxia Type 1 (SCA1) Pathology and Progression<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA1<\/p><p>Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease characterized by progressive muscle weakening and gait impairment, yet no active therapeutics exist to effectively slow disease onset or progression. While various cell types are affected in this disease, the contribution of cell types beyond the cerebellar Purkinje cells is not well understood. Interestingly, we recently identified dysfunctions in oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) in SCA1 that precede Purkinje cell degeneration. In this study, we will aim to elucidate the contribution of oligodendroglia to SCA1 and will determine the mechanisms underlying oligodendroglial dysfunctions, revealing novel potential entry points for therapeutic intervention in various types of ataxias and other neurodegenerative disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-292a410 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"292a410\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0797784\" data-id=\"0797784\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-97b8157 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"97b8157\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7db432d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7db432d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-8ebf1b4\" data-id=\"8ebf1b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8785a4e elementor-widget elementor-widget-image\" data-id=\"8785a4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Soles-Sized.png\" class=\"attachment-large size-large wp-image-21314\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Soles-Sized.png 200w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Soles-Sized-150x150.png 150w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2023\/04\/Soles-Sized-45x45.png 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cdcc578 elementor-widget elementor-widget-text-editor\" data-id=\"cdcc578\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Alyssa Soles<\/b><\/span><\/p><p>University of Minnesota<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-c741591\" data-id=\"c741591\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-03813a1 elementor-widget elementor-widget-text-editor\" data-id=\"03813a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Characterizing Respiratory Dysfunction in Mouse Models of Spinocerebellar Ataxia Type 1<\/em><\/strong><\/p><p><b>Ataxia Type: <\/b>SCA1<\/p><p>Spinocerebellar ataxia type 1 (SCA1) is characterized by degeneration of the brain and spinal cord and in this disorder patients most frequently succumb to problems with swallowing and breathing. This project aims to investigate the underlying cause of breathing dysfunction using mouse models of Spinocerebellar ataxia type 1 (SCA1). The mutant gene that causes SCA1 is widely expressed throughout the body including in skeletal muscle and little is understood about how muscles might be affected by SCA1. Another aim of this project is to assess pathology in muscles from SCA1 mouse models and how this could contribute to problems with breathing. This research will have important implications for the regions that therapies will need to target to extend survival in SCA1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-151bdbf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"151bdbf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9499b9d\" data-id=\"9499b9d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c13577 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3c13577\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7ada45b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ada45b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9cd010f\" data-id=\"9cd010f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7234183 elementor-widget elementor-widget-heading\" data-id=\"7234183\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">View Past Years Funded Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c2b4fc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c2b4fc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-b05c21e\" data-id=\"b05c21e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-18238bb elementor-widget elementor-widget-heading\" data-id=\"18238bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\">2022<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f80e768 elementor-widget elementor-widget-text-editor\" data-id=\"f80e768\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\" data-wplink-edit=\"true\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-a267116\" data-id=\"a267116\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2dc8326 elementor-widget elementor-widget-heading\" data-id=\"2dc8326\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2021-naf-funded-research\/\" target=\"_blank\">2021<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7c47cd elementor-widget elementor-widget-text-editor\" data-id=\"a7c47cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2021-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-e377a40\" data-id=\"e377a40\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86897bc elementor-widget elementor-widget-heading\" data-id=\"86897bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2020-naf-funded-research\/\" target=\"_blank\">2020<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7f74b6 elementor-widget elementor-widget-text-editor\" data-id=\"f7f74b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2020-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-c07cc09\" data-id=\"c07cc09\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b4d1dc elementor-widget elementor-widget-heading\" data-id=\"7b4d1dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">2019<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66cdcbb elementor-widget elementor-widget-text-editor\" data-id=\"66cdcbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2019-naf-funded-research-results\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a799b43 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a799b43\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f811c0f\" data-id=\"f811c0f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23fd10f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"23fd10f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2f5ffc3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2f5ffc3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-42ec0d2\" data-id=\"42ec0d2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19b9cae elementor-widget elementor-widget-heading\" data-id=\"19b9cae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2018\/\" target=\"_blank\">2018<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a5e878 elementor-widget elementor-widget-text-editor\" data-id=\"9a5e878\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2018\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-28df135\" data-id=\"28df135\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9b917a5 elementor-widget elementor-widget-heading\" data-id=\"9b917a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2017\/\" target=\"_blank\">2017<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3e9d68 elementor-widget elementor-widget-text-editor\" data-id=\"f3e9d68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2017\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-f6adc73\" data-id=\"f6adc73\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a875af elementor-widget elementor-widget-heading\" data-id=\"7a875af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2016\/\" target=\"_blank\">2016<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e278d4d elementor-widget elementor-widget-text-editor\" data-id=\"e278d4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2016\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-0868872\" data-id=\"0868872\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f8848b8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f8848b8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cff410d\" data-id=\"cff410d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3802e61 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3802e61\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dc6694c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dc6694c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-55b7a53\" data-id=\"55b7a53\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ecb5f6 elementor-widget elementor-widget-spacer\" data-id=\"3ecb5f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c6dbfd elementor-widget elementor-widget-heading\" data-id=\"6c6dbfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Thank You Donors!<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7932d06 elementor-widget elementor-widget-text-editor\" data-id=\"7932d06\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The generosity of our donors allows NAF to focus on our mission to accelerate the development of treatments and a cure while working to improve the lives of those living with Ataxia. We could not offer this service to the Ataxia research community without you!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>NAF to Award $735,000 in Ataxia research grants in 2023 There was a robust pool of applicants for NAF research grants in 2023. It demonstrates the energy to accelerate treatment <a class=\"MoreInfo\" href=\"https:\/\/www.ataxia.org\/2023-funded-research\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":4,"featured_media":20139,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[517,695,723],"tags":[],"class_list":["post-21301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-naf","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>2023 Funded Research - National Ataxia Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ataxia.org\/2023-funded-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2023 Funded Research - National Ataxia Foundation\" \/>\n<meta property=\"og:description\" content=\"NAF to Award $735,000 in Ataxia research grants in 2023 There was a robust pool of applicants for NAF research grants in 2023. It demonstrates the energy to accelerate treatment Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ataxia.org\/2023-funded-research\/\" \/>\n<meta property=\"og:site_name\" content=\"National Ataxia Foundation\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-17T22:15:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-10T16:28:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2022\/09\/Featured-Image-Size.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Stephanie Lucas\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Stephanie Lucas\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"14 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/\"},\"author\":{\"name\":\"Stephanie Lucas\",\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/#\\\/schema\\\/person\\\/3d2a5fcede7fa9f697ed86fd79c07b27\"},\"headline\":\"2023 Funded Research\",\"datePublished\":\"2023-04-17T22:15:04+00:00\",\"dateModified\":\"2025-02-10T16:28:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/\"},\"wordCount\":2228,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ataxia.org\\\/wp-content\\\/uploads\\\/2022\\\/09\\\/Featured-Image-Size.png\",\"articleSection\":[\"Blog\",\"NAF\",\"Research\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/\",\"url\":\"https:\\\/\\\/www.ataxia.org\\\/2023-funded-research\\\/\",\"name\":\"2023 Funded Research - 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